Multiplexed dynamic PET imaging of the lungs based on triple coincidences
| AUTHORS | |
| JOURNAL | IEEE International Symposium on Biomedical Imaging 2017 |
| ABSTRACT | Multiplexed PET (mPET) is a new imaging technique compatible with any existing PET scanner which allows simultaneous imaging of two PET tracers in vivo. In this work we present initial results of a new procedure to measure liquid absorption (LA) in the airways, a promising biomarker for evaluating treatment response in lung diseases. We performed dynamic PET imaging in the lungs of 10 pigs in a clinical PET scanner using inhaled 13N-NH3 and 76Br-Albumin as tracers.
List mode data from the scanner was analyzed using a custom-developed software to classify events into double- (coming from both tracers) and triple-coincidences (mostly coming from the 76Br-labeled tracer). Both datasets were used to obtain separated dynamic images of each tracer, thus allowing measurement of time-activity curves in the lungs. LA was obtained based on the differences in the clearance of these tracers in the airways. Image quality and quantitative accuracy of this approach has been found to be much better than that achievable using existing approaches such as dual-tracer scintigraphy. |
| LINK | Link |
